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          專職PI
          金偉 研究員
          研究員,博士生導師
          E-mail: jinwei7207@163.com
           

                2006年9月回國來到復旦大學附屬腫瘤醫院乳腺癌研究所工作。作為課題負責人,主持了多項國家自然科學基金,以及教育部新世紀優秀人才基金、上海市浦江人才計劃基金、上海市衛生計生系統優秀學科帶頭人基金、上海市教委科研創新項目、教育部留學回國人員啟動基金、上海市自然科學基金等多項省部級基金;已在國內外期刊雜志上發表論文60余篇,其中SCI論文40余篇,論文發表于Cancer Research、Theranostics、J Biol Chem、Mol Cell Biol、Breast Cancer Res Treat、Biochem Pharmacol 等學術雜志;擔任國家自然科學基金、國家科學技術獎勵等項目和獎勵的通訊評議專家;擔任8家SCI雜志審稿人,還擔任中國抗癌協會抗癌藥物專業委員會委員、上海市抗癌協會乳腺癌專業委員等社會學術職務。


          研究領域:

            主要從事乳腺癌轉移相關的研究,目前主要研究方向包括:
            1.脂質代謝與乳腺癌轉移
          ; 

            2.線粒體相關基因在乳腺癌轉移中的作用;

                  3.轉錄因子與乳腺癌發生發展的研究。


          研究團隊:

            小組成員共7位:孫荷芬(研究助理)、楊雪麗(技術員)、劉洋(博士后)、趙陽(博士研究生)、趙源源(博士研究生)、劉琪琦(博士研究生)、李璇 (博士研究生)。


          代表性論著:

          1. Fu W, Sun H, Zhao Y, Chen M, Yang X, Liu Y, Jin W*. BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation. Theranostics,2019 Aug 21; 9(22):6468-6484.

          2. Liu QQ, Sun HF, Yang XL, Chen MT, Liu Y, Zhao Y, Zhao YY, Jin W*. Survival following radiotherapy in young women with localized early-stage breast cancer according to molecular subtypes. Cancer Med,2019 Jun; 8(6):2840-2857.

          3. Sun HF, Yang XL, Zhao Y, Tian Q, Chen MT, Zhao YY, Jin W*. Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling. Cancer Lett,2019 Jan; 440-441:189-201.

          4. Huang S, Chi Y, Qin Y, Wang Z, Xiu B, Su Y, Guo R, Guo L, Sun H, Zeng C, Zhou S, Hu X, Liu S, Shao Z, Wu Z, Wei J*, Wu J*. CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription. Theranostics, 2018; 8(9): 2549-2564.

          5. Chen MT, Sun HF, Li LD, Zhao Y, Yang LP, Gao SP, Jin W*. Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway. Oncol Lett, 2018 Jun; 15(6): 8582-8588.

          6. Zhao Y, Sun HF, Chen MT, Gao SP, Li LD, Jiang HL, Jin W*. Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study. Cancer Med, 2018 Jun; 7(6):2307-2318.

          7. Yang LP, Sun HF, Zhao Y, Chen MT, Zhang N*, Jin W*. Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study. Cancer Med, 2017 Dec; 6(12):2867-2875.

          8. Chen MT, Sun HF, Zhao Y, Fu WY, Yang LP, Gao SP, Li LD, Jiang HL, Jin W*. Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis. Sci Rep, 2017 Aug 23; 7(1):9254.

          9. Gao SP, Sun HF, Li LD, Fu WY, Jin W*. UHRF1 promotes breast cancer progression by suppressing KLF17 expression by hypermethylating its promoter. Am J Cancer Res, 2017 Jul 1; 7(7):1554-1565.

          10. Gao SP, Sun HF, Fu WY, Li LD, Zhao Y, Chen MT, Jin W*. High expression of COX5B is associated with poor prognosis in breast cancer. Future Oncol, 2017 Aug;13(19):1711-1719.

          11. Jiang HL, Sun HF, Gao SP, Li LD, Huang S, Hu X, Liu S, Wu J, Shao ZM, Jin W*. SSBP1 Suppresses TGFβ-Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling. Cancer Res, 2016 Feb 15; 76(4):952-64.

          12. Li LD, Sun HF, Liu XX, Gao SP, Jiang HL, Hu X, Jin W*. Down-Regulation of NDUFB9 Promotes Breast Cancer Cell Proliferation, Metastasis by Mediating Mitochondrial Metabolism. PLoS One, 2015 Dec 7; 10(12).

           
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